Institut des
NanoSciences de Paris
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Coherent nanoprobes for multiphoton imaging in turpid media - Rachel Grange - 11 décembre 2014 à 16 h

INSP - 4 place Jussieu - 75252 PARIS Cedex 05 - Barre 22-23 - 3e étage, salle 317

Rachel Grange - ETH Zurich


Nonlinear optical properties such as second-harmonic generation (SHG) are key effects to realize interesting applications in biophotonics. Compared to conventional fluorescence,harmonic generation possess several advantages, including long-term observation without photobleaching, flexibility in excitation wavelength, coherent signals for three-dimensional imaging and scattering corrected applications, narrow signal bandwidth for greater noise rejection, ultrafast response time, and excellent biocompatibility. Such outstanding properties can be applied to several domains, particularly where deep tissue and long-term optical investigations are needed like in neurosciences, developmental biology and cancer diagnostics. My research encompass the synthesis of the second-harmonic nanoparticles or nanowires, the investigation of their optical properties, the development of advanced nonlinear microscopy setup for enlarging the imaging toolbox and the applications to biology. Here I will present recent results about the smallest possible nanoprobes and their brightness for in vivo imaging. Then, I will focus on two types of coherent imaging modalities using nanoprobes : harmonic holography and phase conjugation. Finally, I will discuss fluorescent excitation using LiNbO3 nanowires as local light waveguide.for Local Fluorescence